Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats
- 28 September 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 101 (7), 734-741
- https://doi.org/10.1161/circresaha.107.153023
Abstract
Pulmonary arterial hypertension (PAH) is a fatal disease associated with inflammation and pathological remodeling of the pulmonary artery (PA). Interleukin (IL)-10 is a pleiotropic antiinflammatory...Keywords
This publication has 28 references indexed in Scilit:
- Mycophenolate mofetil attenuates pulmonary arterial hypertension in ratsBiochemical and Biophysical Research Communications, 2006
- Repair of Infarcted Myocardium Mediated by Transplanted Bone Marrow–Derived CD34 + Stem Cells in a Nonhuman Primate ModelThe International Journal of Cell Cloning, 2005
- Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient miceGene Therapy, 2004
- Treatment of Pulmonary Arterial HypertensionNew England Journal of Medicine, 2004
- IL-10 inhibits vascular smooth muscle cell activation in vitro and in vivoAmerican Journal of Physiology-Heart and Circulatory Physiology, 2004
- Interleukin-1β, Transforming Growth Factor-β 1 , and Bradykinin Attenuate Cyclic AMP Production by Human Pulmonary Artery Smooth Muscle Cells in Response to Prostacyclin Analogues and Prostaglandin E 2 by Cyclooxygenase-2 Induction and Downregulation of Adenylyl Cyclase Isoforms 1, 2, and 4Circulation Research, 2004
- Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in miceNature Medicine, 2002
- Interleukin-10 Inhibits Human Vascular Smooth Muscle ProliferationJournal of Molecular and Cellular Cardiology, 1998
- The role of vascular injury and hemodynamics in rat pulmonary artery remodeling.JCI Insight, 1996
- Pulmonary Hypertension in Rats 1.International Archives of Allergy and Immunology, 1995