Alcohol Withdrawal Syndromes in the Human: Comparison with Animal Models
- 1 January 1977
- book chapter
- Published by Springer Nature
Abstract
Alcohol withdrawal syndromes in humans lie on a continuum of increasing severity, from the acute hangover to delirium tremens. Early mild reactions consist primarily of hyperexcitability phenomena such as tremor, insomnia, hyperreflexia and hyperventilation. In more severe degree, the same process gives rise to hallucinations and seizures. These early reactions are mimicked closely by alcohol withdrawal signs in experimental animals. Late reactions in humans are characterized by marked sympathetic nervous system overactivity, profound disorientation and hallucinations. Analogous reactions have not yet been observed clearly in other species. The problem may be one of finding appropriate techniques for detecting such changes, rather than a true species difference in their occurrence.This publication has 12 references indexed in Scilit:
- WITHDRAWAL PSYCHOSIS: A STUDY OF 30 CONSECUTIVE CASESActa Psychiatrica Scandinavica, 1976
- Propranolol Effect on Tremor in Alcoholic WithdrawalAnnals of Internal Medicine, 1975
- Induction of physical dependence upon ethanol and the associated behavioral changes in ratsPsychopharmacology, 1975
- Acute Alcohol Withdrawal SyndromePublished by Springer Nature ,1974
- A review of methods to induce alcohol addiction in animalsPharmacology Biochemistry and Behavior, 1973
- Alcohol Dependence Produced in Mice by Inhalation of Ethanol: Grading the Withdrawal ReactionScience, 1971
- Convulsions and Hallucinatory BehaviorArchives of Neurology, 1968
- Comparative Clinical Evaluation of Chlordiazepoxide and Promazine in Treatment of Alcohol-withdrawal SyndromeBMJ, 1965
- DEGREE OF PHYSICAL DEPENDENCE INDUCED BY SECOBARBITAL OR PENTOBARBITALJAMA, 1958
- Tolerance to and Physical Dependence on Opiates, Barbiturates, and AlcoholAnnual Review of Medicine, 1957