Thermodynamic considerations in co-ordination. Part XXII. Sequestering ligands for improving the treatment of plumbism and cadmiumism

Abstract

Potentiometrically determined formation constants are reported for cadmium(II), lead(II), and zinc(II) with ethylenediaminetetra-acetic acid, 1,2,di(2-aminoethoxy)ethanetetra-acetic acid, glutathione, cysteine, and D-penicillamine at 25 °C, I= 3.00M(NaClO₄). Computer-simulated models of blood plasma conditions were used to examine the complexing competition between cadmium(II) and zinc(II), and lead(II) and zinc(II), with these ligands. It was concluded that glutathione is the most promising ligand for future clinical studies.