Refractory Anemia with Abnormal Iron Metabolism

Abstract

MEDIASTINAL-lymph-node hyperplasia resembling thymoma was first recognized as an entity by Castleman in 1954,¹ although 3 cases of "enlarged inflammatory lymph nodes" had previously been described in 1946,² in a series of 109 patients operated on for mediastinal tumors. Subsequently, Castleman, Iverson and Pardo Menendez³ presented a series of 13 cases, including 2 that had previously been classified as thymoma.^{4 , 5} The characteristic pathological features noted were germinal-center formation and marked capillary endothelial proliferation. These findings were consistent with hyperplasia and not neoplasia. Many similar cases have been reported.^{6 7 8 9 10 11 12 13 14 15 16} In none of the approximately 30 cases in the world literature was . . .