Postmortem and Regional Changes of Serotonin, 5‐Hydroxyindoleacetic Acid, and Tryptophan in Brain
- 1 June 1984
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 42 (6), 1588-1592
- https://doi.org/10.1111/j.1471-4159.1984.tb12746.x
Abstract
Using a specific and sensitive high pressure liquid chromatographic technique for the measurement of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), and tryptophan (TRP), we found that there were no changes in 5-HT or 5-HIAA in the rat cortex when left in situ for 6 h at room temperature or 24 h at 4°C. Only a minimal 14% increase in 5-HT was observed after 24 h at 4°C in the striatum of the same animals. Concentrations of TRP, however, were increased significantly in both brain regions by these postmortem delay procedures. A second study revealed that there were significant regional 5-HT and 5-HIAA concentration differences within the cerebral cortex. The frontal cortex was shown to have the highest concentrations of 5-HT and 5-HIAA. Further, within the frontal cortex, 5-HIAA levels varied, showing apparent progressive rostral to caudal increases. 5-HT concentrations, however, remained constant within the frontal cortex. These results are discussed in reference to the conflicting reports of the previous human suicide and postmortem studies.Keywords
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