Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins.
Open Access
- 15 September 1996
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 10 (18), 2302-2313
- https://doi.org/10.1101/gad.10.18.2302
Abstract
The activation signal from tyrosine kinase receptors, such as the epidermal growth factor receptor (EGFR), is relayed via a highly conserved intracellular pathway involving Ras, Raf, and MAPK. In Drosophila, the EGFR and components of the intracellular pathway are broadly expressed, yet receptor activation evokes tissue-specific cell responses. Extracellular events that lead to receptor activation are one mechanism by which signaling is modulated. Here we show molecular and genetic evidence that Drosophila vein (vn) encodes a candidate EGFR ligand and that vn expression is spatially restricted. Consequently, vn may promote tissue-specific receptor activation. Unlike two other ligands, Gurken (Grk) and Spitz (Spi), which are transforming growth factor alpha-like proteins, Vn has both an immunoglobulin-like and an EGF-like domain. This combination of domains mirrors those in the vertebrate neuregulins that bind EGFR relatives.Keywords
This publication has 70 references indexed in Scilit:
- Polarization of both major body axes in Drosophila by gurken-torpedo signallingNature, 1995
- Tyrosine Kinase Inhibition: An Approach to Drug DevelopmentScience, 1995
- A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signalingCell, 1994
- The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGFα-like proteinCell, 1993
- The gene lin-3 encodes an inductive signal for vulval development in C. elegansNature, 1992
- Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unitCell, 1992
- Expression during Drosophila development of DER, a gene related to erbB-1 and neu: Correlations with mutant phenotypesDevelopmental Biology, 1991
- Developmental control by the Drosophila EGF receptor homolog DERTrends in Genetics, 1991
- The Immunoglobulin Superfamily—Domains for Cell Surface RecognitionAnnual Review of Immunology, 1988
- Rat epidermal growth factor: complete amino acid sequenceEuropean Journal of Biochemistry, 1985