Clostridium difficile: progress and challenges
- 22 December 2010
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1213 (1), 62-69
- https://doi.org/10.1111/j.1749-6632.2010.05863.x
Abstract
There is a surge of new interest in C. difficile infection (CDI) reflecting substantial increases in cases and fatalities. The new challenges by this now old pathogen have brought renewed interest in all facets of the disease. Particularly important are the role of fluoroquinolones as inducing agents, the new polymerase chain reaction test to detect toxigenic strains in stools, the important role of the NAP-1 strain, recent evidence favoring oral vancomycin over metronidazole in seriously ill patients, and new guidelines for management.This publication has 78 references indexed in Scilit:
- Evaluation of the C.Diff Quik Chek Complete Assay, a New Glutamate Dehydrogenase and A/B Toxin Combination Lateral Flow Assay for Use in Rapid, Simple Diagnosis of Clostridium difficile DiseaseJournal of Clinical Microbiology, 2010
- Clostridium difficileInfections among Hospitalized Children, United States, 1997–2006Emerging Infectious Diseases, 2010
- Multicenter Study of Surveillance for Hospital-Onset Clostridium difficile Infection by the Use of ICD-9-CM Diagnosis CodesInfection Control & Hospital Epidemiology, 2010
- C. Diff Quik Chek Complete Enzyme Immunoassay Provides a Reliable First-Line Method for Detection of Clostridium difficile in Stool SpecimensJournal of Clinical Microbiology, 2010
- Emergency subtotal colectomy for fulminant Clostridium difficile colitis – is a surgical solution considered for all patients?The Annals of The Royal College of Surgeons of England, 2010
- Comparison of BD GeneOhm Cdiff Real-Time PCR Assay with a Two-Step Algorithm and a Toxin A/B Enzyme-Linked Immunosorbent Assay for Diagnosis of Toxigenic Clostridium difficile InfectionJournal of Clinical Microbiology, 2010
- Comparison of a Commercial Real-Time PCR Assay for tcdB Detection to a Cell Culture Cytotoxicity Assay and Toxigenic Culture for Direct Detection of Toxin-Producing Clostridium difficile in Clinical SamplesJournal of Clinical Microbiology, 2009
- Patterns of antibiotic use and risk of hospital admission because of Clostridium difficile infectionCMAJ : Canadian Medical Association Journal, 2008
- Increase inClostridium difficile–related Mortality Rates, United States, 1999–2004Emerging Infectious Diseases, 2007
- Impact of Emergency Colectomy on Survival of Patients With Fulminant Clostridium difficile Colitis During an Epidemic Caused by a Hypervirulent StrainAnnals of Surgery, 2007