A trial of imidazole carboxamide and corynebacteriumparvum in disseminated melanoma. Clinical and immunologic results
- 1 August 1980
Abstract
Nonspecific immunotherapy with monthly intramuscular (IM) injections of Corynebacterium parvum has been investigated in patients with disseminated melanoma. Forty-nine patients were randomized to receive either imidazole carboxamide (DTIC) alone or DTIC plus C parvum. A 24% overall objective response rate was observed, with no significant difference between the response rate or survival of the two treatment groups. Immunologic studies revealed no significant difference between the two groups. One patient undergoing chemoimmunotherapy demonstrated profound pancytopenia which responded to cessation of therapy, but toxic reactions were otherwise minimal. No advantage was obtained by adding IM injected C parvum to standard chemotherapy in the treatment of disseminated melanoma. Cancer 46:475–479, 1980.This publication has 19 references indexed in Scilit:
- Combination chemotherapy of malignant melanoma with imidazole carboxamide, BCNU and vincristineCancer, 1976
- IMMUNOCHEMOTHERAPY WITH CORYNEBACTERIUM PARVUM IN DISSEMINATED CANCER*Annals of the New York Academy of Sciences, 1976
- Observations followingCorynebacterium parvum administration to patients with advanced malignancy.A phase I studyCancer, 1976
- The Effect of Intravenous and Intramuscular Injection of Corynebacterium parvumPublished by Springer Nature ,1975
- Corynebacterium parvum: Preliminary Report of a Phase I Clinical and Immunological Study in Cancer PatientsPublished by Springer Nature ,1975
- Comparative Studies on the Effect of Corynebacterium parvum on Bone-Marrow Cell Colony Formation in VitroPublished by Springer Nature ,1975
- Integration of chemotherapy into combined modality therapy of solid tumors: IV. Malignant melanomaCancer Treatment Reviews, 1974
- An improved rosetting assay for detection of human T lymphocytesJournal of Immunological Methods, 1974
- Active Immunotherapy with Corynebacterium parvum and Chemotherapy in Murine FibrosarcomasBMJ, 1970
- Immunochemical quantitation of antigens by single radial immunodiffusionImmunochemistry, 1965