Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans
- 1 August 2001
- Vol. 36 (8), 761-766
- https://doi.org/10.1007/s11745-001-0782-9
Abstract
The biosynthetic pathway for polyunsaturated fatty acids in the model animal Caenorhabditis elegans was examined in the context of the completed genome sequence. The genomic organization and location of seven desaturase genes and one elongase activity, all previously identified by functional characterization, were elucidated. A pathway for the biosynthesis of polyunsaturated fatty acids in C. elegans was proposed based on these genes. The role of gene duplication in enzyme evolution and proliferation is discussed.Keywords
This publication has 47 references indexed in Scilit:
- Broadcast interference – functional genomicsTrends in Genetics, 2001
- A Palmitoyl-CoA-Specific Δ9 Fatty Acid Desaturase from Caenorhabditis elegansBiochemical and Biophysical Research Communications, 2000
- Functional identification of a fatty acid Δ5 desaturase gene from Caenorhabditis elegansFEBS Letters, 1998
- Site‐directed mutagenesis of histidine residues in the Δ12 acyl‐lipid desaturase of SynechocystisFEBS Letters, 1995
- About turn for the COPs?Cell, 1994
- 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegansNature, 1994
- De novo biosynthesis of linoleic acid in two non-insect invertebrates: The land slug and the garden snailCellular and Molecular Life Sciences, 1993
- Characterization of the Δ12 desaturase in the American cockroach, Periplaneta americana: The nature of the substrateBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
- Basic local alignment search toolJournal of Molecular Biology, 1990
- Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulumCell, 1989