Pancreatitis as an Adverse Reaction to Salicylazosulfapyridine

Abstract

ADVERSE reactions to drugs of the sulfonamide family have been reported to involve all major organ systems.¹ Anaphylactoid reactions² and serum-sickness-like syndromes have also been described.³ Barrett and Thier⁴ presented a case of pancreatitis induced by sulfamethizole; however, a causal relation was not well documented. On the basis of an elevated lipase level, Nidus et al.⁵ suggested pancreatic involvement in a patient with salivary-gland enlargement attributed to sulfasoxazole. In the case of regional enteritis reported below, several episodes of pancreatitis were induced by the administration of salicylazosulfapyridine (Azulfidine). To the best of our knowledge this is the first case implicating . . .