Electrofocusing and Electrophoresis of Cerebrospinal Fluid Proteins in CNS Disorders of Known or Probable Infectious Etiology

Abstract

The CSF and sera of 17 patients with meningoencephalitis or encephalitis, 10 with meningitis or meningomyelitis, 5 subjects with postencephalitic sequelae and 2 with arachnoiditis were studied. Diseases involving the intracranial CNS parenchyma gave CSF electrofocusing findings differing from those of the other diagnostic subgroups. Differences regarding subfraction patterns of the .gamma.-globulin region seemed to be influenced of whether supra- or infratentorial structures were affected. The abnormal CSF-protein patterns found on electrofocusing were apparently not only influenced by temporal but also by spatial factors.