Acute optic neuritis: a prospective study of risk factors for multiple sclerosis.
Open Access
- 1 October 1986
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 49 (10), 1125-1130
- https://doi.org/10.1136/jnnp.49.10.1125
Abstract
Eighty two patients with isolated optic neuritis were studied prospectively to determine the frequency with which multiple sclerosis developed and the factors which increased its risk. Patients were followed for 6 to 264 months (mean, 57 months). Twenty six patients (32%) developed clinically definite or probable multiple sclerosis during the period of follow-up. Actuarial analysis predicted that 42% would develop multiple sclerosis by 7 years. Of those patients who developed multiple sclerosis, 92% had symptoms within 4 years of the first attack of optic neuritis. The highest incidence of multiple sclerosis occurred in the 21-40 year age group. There was an increased risk of MS in patients with HLA-DR2 and HLA-B7 tissue types. The frequency of HLA-DR4 was increased in patients with optic neuritis alone compared to controls and to patients with multiple sclerosis, but further studies are required to confirm this finding.This publication has 28 references indexed in Scilit:
- OPTIC NEURITIS-A SIGN OF MULTIPLE SCLEROSIS OR OTHER DISEASES OF THE CENTRAL NERVOUS SYSTEMActa Neurologica Scandinavica, 2009
- Optic neuritis and distribution of genetic markers of the HLA systemActa Neurologica Scandinavica, 2009
- BILATERAL OPTIC NEURITISBrain, 1984
- The incidence of optic neuritis and its prognosis for multiple sclerosisActa Neurologica Scandinavica, 1983
- A prospective study of the risk of developing multiple sclerosis in optic neuritis in a tropical and sub-tropical area.Journal of Neurology, Neurosurgery & Psychiatry, 1983
- Acute optic neuritis and the prognosis for multiple sclerosis.Journal of Neurology, Neurosurgery & Psychiatry, 1976
- HL-A HISTOCOMPATIBILITY ANTIGENS IN OPTIC NEURITISActa Neurologica Scandinavica, 1975
- ACUTE RETROBULBAR NEURITIS ‐A RETROSPECTIVE STUDYActa Ophthalmologica, 1972
- Acute optic neuritis: prognosis for development of multiple sclerosis.Journal of Neurology, Neurosurgery & Psychiatry, 1968
- SURVIVAL DATA OF RENAL TRANSPLANTATIONS IN PATIENTSTransplantation, 1965