A structurally abnormal insulin causing human diabetes
- 1 September 1979
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 281 (5727), 122-125
- https://doi.org/10.1038/281122a0
Abstract
Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalamine substitution at position 24 or 25 of the insulin B-chain.Keywords
This publication has 26 references indexed in Scilit:
- Treatment by Plasma Exchange of a Patient with Autoantibodies to the Insulin ReceptorNew England Journal of Medicine, 1979
- Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinctionMetabolism, 1978
- Insulin resistance due to a defect distal to the insulin receptor: Demonstration in a patient with leprechaunismProceedings of the National Academy of Sciences, 1978
- Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action.Journal of Clinical Investigation, 1976
- Familial HyperproinsulinemiaNew England Journal of Medicine, 1976
- The Syndromes of Insulin Resistance and Acanthosis NigricansNew England Journal of Medicine, 1976
- Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin ResistanceScience, 1975
- DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS*Annals of the New York Academy of Sciences, 1964
- The isolation of insulin from a single cat pancreasBiochimica et Biophysica Acta, 1962
- Disk Electrophoresis of Basic Proteins and Peptides on Polyacrylamide GelsNature, 1962