TUMOR-PRODUCING EFFECT OF AUTOMOBILE EXHAUST CONDENSATE AND FRACTIONS THEREOF .3. MATHEMATICAL-STATISTICAL EVALUATION OF THE TEST-RESULTS

Abstract

The mathematical-statistical evaluation of several carcinogenesis experiments are discussed including the extent of dose-dependence on carcinogenic potency of automobile exhaust gas condensate, identification of the fractions (groups of substances) of the automobile exhaust gas condensate which are mainly responsible for the carcinogenic potency and the extent to which the potency can be explained by fractions (or single substances)? Animal experiments with prepared and fractionalized automobile exhaust gas condensate were planned. The exhaust gas condensate and its fractions were dropped onto the skin of female CFLP mice. The aim of the mathematical-statistical evaluation was to establish the dose-response relations, to assess the combined effect and to estimate the relative potency and the assumed potency. The hypothesis (basis for the separation process) that the potency of the entire exhaust gas condensate is mainly attributable to the fraction which contains the polycyclic aromatic hydrocarbons (nitromethane phase) was examined.