Influence of Pituitary Adrenotrophic Hormone on Lymphoid Tissue Structure in Relation to Serum Proteins.

Abstract

Summary Decrease of lymphocytes in lymphoid tissue and the concomitant lymphopenia following injection of pituitary adrenotrophic hormone, or adrenal cortical extract, are in their time relationships correlated with an increase in serum proteins. These same relationships persist in animals given daily injections of adrenotrophic hormone. Adrenalectomized mice, in which hemoconcentration is prevented, have a lower than normal concentration of serum proteins for at least 8 days following operation.