LOSS OF RECENT MEMORY IN MICE AS RELATED TO REGIONAL INHIBITION OF CEREBRAL PROTEIN SYNTHESIS

Abstract

Evidence has been obtained that loss of recent memory of simple maze learning in mice following bilateral temporal injections of puromycin is related to the degree and duration of inhibition of protein synthesis in the hippocampi and temporal cortices. Failure of puromycin subcutaneously injected, and of intracerebrally injected chloramphenicol to affect memory is related to their inadequate effect on degree and duration of inhibition of protein synthesis.