Periapical innervation of the ferret canine and the local retrograde neural changes after pulpectomy

Abstract

The amputation of the dental pulp severs a population of axons that are predominantly in the Aδ and C fiber size range and are principally involved in nociception. Local periapical neuromas, if they are formed after pulpectomy, may be the sites of spontaneous nervous activity that may, in some circumstances, be involved in the genesis of chronic pain. The periapical tissues from the mandibular canines of four ferrets were examined 3 months after pulpectomies. Silver-stained paraffin sections were examined in three dimensions at the light microscope level. Ultrathin sections were examined at the electron microscope level. Compared with contralateral and independent controls, the principal changes were the loss of the periodontal plexus around the root apex, the extension of damage well below the apical foramen, and the persistance of inflammation 12 weeks postoperatively. While a somewhat disorderly mass of nerve fibers develops subapically, the arrangement has only some of the features usually associated with neuromas.