Cutting Edge: A New Approach to Modeling Early Lung Immunity in Murine Tuberculosis
- 1 March 2004
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 172 (5), 2748-2751
- https://doi.org/10.4049/jimmunol.172.5.2748
Abstract
In this study, we report a new approach that allows dissection of distinct pathways regulating induction of early adaptive immunity in response to Mycobacterium tuberculosis (Mtb). We used traceable murine dendritic cells (DCs) and macrophage populations to chart their migratory pattern in response to Mtb, and found that only DCs receiving inflammatory stimuli from Mtb up-regulated their expression of CCR7 and migrated specifically to the draining lymph nodes (LNs). Furthermore, these Mtb-modulated DCs initiated a Th1 response only in the draining LNs. Taken together, these results demonstrate that Mtb-induced modulation of DCs is critical for their migration to regional LNs and ensuing T cell priming.Keywords
This publication has 19 references indexed in Scilit:
- Accelerated Migration of Respiratory Dendritic Cells to the Regional Lymph Nodes Is Limited to the Early Phase of Pulmonary InfectionImmunity, 2003
- Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situJournal of Clinical Investigation, 2002
- Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situJournal of Clinical Investigation, 2002
- Immunology of TuberculosisAnnual Review of Immunology, 2001
- Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph NodesThe Journal of Experimental Medicine, 2000
- Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiationEuropean Journal of Immunology, 2000
- An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowJournal of Immunological Methods, 1999
- T cell genetic background determines default T helper phenotype development in vitro.The Journal of Experimental Medicine, 1995
- Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection.The Journal of Experimental Medicine, 1992
- Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.The Journal of Experimental Medicine, 1986