In vitro cytotoxicity of lymphocytes from patients with "acquired" and sex-linked agammaglobulinaemia.
- 1 November 1971
- journal article
- Vol. 9 (5), 603-9
Abstract
The in vitro cytotoxicity for fowl erythrocytes of circulating lymphocytes from nine patients with `acquired' and three patients with sex-linked agammaglobulinaemia was tested by release of sodium chromate (51Cr) after 42 hr of culture in the presence of phytohaemagglutinin (PHA). The lymphocyte cytotoxicity of three patients with `acquired' agammaglobulinaemia was low, but that of the other six and of the three patients with sex-linked agammaglobulinaemia were normal. All the `acquired' agammaglobulinaemic patients had markedly diminished thymidine uptake in response to PHA at 3 days, but a normal response at 7–10 days, but the three boys with sex-linked agammaglobulinaemia showed a normal response. The findings further demonstrate the heterogeneity of lymphocyte abnormalities in patients with agammaglobulinaemia.This publication has 10 references indexed in Scilit:
- Clinical, serologic and leukocyte function studies on patients with idiopathic “acquired” agammaglobulinemia and their familiesAmerican Journal Of Medicine, 1970
- Human Lymphocyte Response to Phytomitogens in Vitro: Normal, Agammaglobulinemic and Paraproteinemic IndividualsThe Journal of Immunology, 1969
- Non-specific induction of cytotoxicity in normal human lymphocytes in vitro: studies of mechanism and specificity of the reaction.1969
- Cytotoxic Action of Stimulated Lymphocytes on Allogenic and Autologous ErythrocytesScience, 1968
- Lymphocyte Response to Antigens. B. Efferent Side of Sensitization ArcTransplantation, 1967
- Impaired phytohaemagglutinin-induced cytotoxicity in vitro of lymphocytes from patients with Hodgkin's disease or chronic lymphatic leukaemia.1967
- CYTOTOXIC POTENTIAL OF STIMULATED HUMAN LYMPHOCYTESThe Journal of Experimental Medicine, 1967
- QUANTITATIVE STUDIES ON PHYTOHAEMAGGLUTININ-INDUCED CYTOTOXICITY BY HUMAN LYMPHOCYTES AGAINST HOMOLOGOUS CELLS IN TISSUE CULTURE1967
- Agammaglobulinemia: The Fundamental DefectScience, 1964
- TRANSPLANTATION STUDIES IN PATIENTS WITH AGAMMAGLOBULINEMIAAnnals of the New York Academy of Sciences, 1957