COMPARISON OF CHLOROQUINE, QUINACRINE (ATABRINE), AND QUININE IN THE TREATMENT OF ACUTE ATTACKS OF SPOROZOITE-INDUCED VIV AX MALARIA (CHESSON STRAIN) 1
Open Access
- 30 April 1948
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 27 (3 Pt 2), 46-50
- https://doi.org/10.1172/jci101970
Abstract
Chloroquine was tested in a small series of cases under controlled conditions and compared with quinine and quinacrine. Both chloroquine and quinacrine cleared the blood of parasites in most of the cases more rapidly than did quinine. The relapse rate after treatment with all 3 drugs was about the same, 90% or over. The latent period following therapy for 50% of patients treated with quinine, quinacrine, and chloroquine, was 15 days, 34 days, and 64 days, respectively. Chloroquine was superior to quinacrine and quinine for the treatment of this series of acute attacks of vivax malaria.Keywords
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