A study of the passage of fatty acids of food into lipins and glycerides of the body using deuterium as an indicator

Abstract

Rats were fed with a fat containing 4-5 atoms % deuterium and the distr. of the "deutero-fatty acids" in "lipin" and "glyceride" fractions of liver, kidney, brain and blood detd. 6, 10 and 24 hr. after. After 6 hr. D was present in considerable amt. in plasma glycerides, liver glycerides and liver lipins. There was much less in the lipoid fractions of the kidney and plasma and the D was only present in traces in brain and adipose tissue. The D in the liver glycerides decreased more rapidly in 24 hr. than that of the liver lipins. In the lipoid fractions of kidney and brain there were no notable changes in % D between 6 and 24 hr. The results suggest that liver lipins may play a very active part in fat metabolism.