Alpha-methylhistamine methylation by histamine methyltransferase
- 1 November 1981
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 11 (5), 425-428
- https://doi.org/10.1007/bf02004701
Abstract
Enzymatic methylation of histamine and analogues by histamine methyltransferase (HMT) was studied. Incubation of histamine or alpha-methylhistamine with HMT and S-adenosylmethionine was shown by GC-MS to yield tele-methyl and alpha-methyl-tele-methyl-histamine, respectively. Kinetic analysis of the reactions indicated that both substrates exhibited equivalentV max values, but that histamine'sK m was ten-fold lower than that of alphamethylhistamine. these results indicate that alphamethylhistamine can be methylated as effectively as histamine, and may be a useful tool in further studies of HMT.This publication has 17 references indexed in Scilit:
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