EFFECT OF DIETARY WEIGHT-LOSS ON SEX STEROID BINDING, SEX STEROIDS, AND GONADOTROPINS IN OBESE POST-MENOPAUSAL WOMEN
- 1 January 1979
- journal article
- research article
- Vol. 93 (6), 1004-1008
Abstract
SSBG [sex steroid binding globulin], E2 [estradiol], T [testosterone], and gonadotropins were measured in 12 obese postmenopausal women before, during and after a supplemented fast. Weight loss (mean 18 kg) was associated with an increase in SSBG to levels above those seen in non-obese postmenopausal women, a decrease in serum E2 levels, unchanged T levels and an increase in both gonadotropins. Weight change or the circumstances associated with it lead to alterations in circulating levels of SSBG. These observations are consistent with the presence of elevated free T and possibly higher free E2 levels in obese postmenopausal women.Keywords
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