Report of Familial Cases of Parkinsonism

Abstract
PARKINSONISM is not generally considered to be hereditary. Many textbooks of neurology mention only that cases have been reported in which heredity appeared to play a part. However, the impression that parkinsonism has a hereditary tendency has been documented by a number of authors. Doshay feels that idiopathic parkinsonism has a well-defined hereditary liability, that it is related to myoclonic epilepsy, and that both these conditions represent a form of "cumulative metabolic neuronal lipoidosis." Medea and Clerice in 1898 reported the illness to be present in 4 of 10 siblings. In 1899 Collins and Muskins commented on the high incidence of this affliction in the Irish, and 4 of their reported 24 patients had "a straight forward history of direct inheritance." In these 4, one of the parents was afflicted, and in 3 of the 4 cases an aunt or an uncle also had the disease. Hart in 1904 reported