The Acid-Base Composition of Gastric Juice During the Secretory Cycle

Abstract

Gastric secretion was collected from two healthy laboratory workers, one patient, and a dog with a Pavlov pouch. The fasting juice was collected and then histamin was given. Study was made of the amount of acid, chlorides, total base, Na, K and Ca. During the secretory cycle the concentration of base varies inversely as the concentration of acid. Sodium seemed to be the most important of the individual bases, both in regard to the amount and the way in which it varied during the secretory cycle. The concentration of K was 3-5 times greater in the gastric juice than in the blood serum. The concentration of the other ions studied was less in the gastric juice than in the blood.