Oxygen Radicals in Focal Cerebral Ischemia
- 28 January 1994
- journal article
- review article
- Published by Wiley in Brain Pathology
- Vol. 4 (1), 59-65
- https://doi.org/10.1111/j.1750-3639.1994.tb00811.x
Abstract
Oxygen free radicals have been widely implicated in the pathogenesis of brain injury due to ischemia followed by reperfusion. The success of making transgenic animals overexpressing human CuZn-superoxide dismutase (CuZn-SOD) in brain cells allows researchers to discern the specific role of superoxide radicals in reperfusion injury after focal ischemia. It has been shown that increased brain levels of CuZn-SOD in transgenic mice protect neurons from ischemia/reperfusion injury. However, overexpression of CuZn-SOD does not provide neuronal protection in permanent focal ischemia in mice, when compared with non-transgenic mouse littermates. It is proposed that molecular genetic approaches of modifying antioxidant levels in the brain offer a unique tool for studying oxidative mechanisms in focal cerebral ischemia.Keywords
This publication has 48 references indexed in Scilit:
- Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.Stroke, 1994
- Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemiaNeuroReport, 1993
- Effects of Nitric Oxide Synthase Inhibition on Cerebral Blood Flow following Bilateral Carotid Artery Occlusion and Recirculation in the RatJournal of Cerebral Blood Flow & Metabolism, 1993
- Nitroprusside improves blood flow and reduces brain damage after focal ischemiaNeuroReport, 1993
- Blockade of nitric oxide formation by Nω-nitro-l-arginine mitigates ischemic brain edema and subsequent cerebral infarction in ratsNeuroscience Letters, 1992
- Edema, cation content, and ATPase activity after middle cerebral artery occlusion in rats.Stroke, 1992
- Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats.Stroke, 1992
- Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats.Stroke, 1990
- Reversible middle cerebral artery occlusion without craniectomy in rats.Stroke, 1989
- A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction.Stroke, 1986