An Inactivated Hepatitis A Virus Vaccine Prepared from Infected Marmoset Liver

Abstract

Human hepatitis A virus, partially purified from the liver of a rufiventer marmoset infected with CR326 strain virus, was inactivated with formalin and was highly potent in stimulating homologous antibody in marmosets when administered s.c. at bi-weekly intervals in 8 divided doses. The vaccine prevented hepatitis A in all marmosets when challenged with live hepatitis A virus in a controlled study.