PROLACTIN-LOWERING EFFECT OF LOW DOSES OF LISURIDE IN MAN

Abstract

Lisuride, a new semisynthetic ergot derivative, effectively decreased the TRH[thyrotropin]-induced hyperprolactinemia in healthy female volunteers at an oral dose of 300 .mu.g. Basal prolactin levels were suppressed after a single dose of 100 and 200 .mu.g lisuride. This effect was still present 6 h after administration. Lisuride (200 .mu.g) also decreased the high serum prolactin levels produced by i.m. injection of 50 mg sulpiride, and conversely, sulpiride injection abolished the prolactin lowering effect of lisuride. In man, lisuride is a very potent prolactin-lowering agent. A predominant role of dopaminergic mechanisms in the regulation of prolactin secretion is apparent.