Challenges: Observing development through evolutionary eyes: A practical approach
- 1 April 1992
- Vol. 14 (4), 281-287
- https://doi.org/10.1002/bies.950140414
Abstract
An argument is made that only through a detailed comparison of mutational mechanisms underlying the evolution of the genetic systems governing development, can the 'logic' of individual development be fully comprehended. To do this, it is essential to choose two or more genes (or their products) that interact in the establishment of a given function, and to compare the molecular basis of that interaction in closely related species. The rationale to this approach arises from observations of molecular co‐evolution between interacting partners involved with given functions which have led to species specificity in the manner in which such functions are effected. Molecular coevolution reveals that divergence in sequence can be tolerated whilst biological functions are maintained, not because it is neutral and dispensable but because successful, compensatory changes can evolve in eukaryotic genomes that are in continuous states of flux.Keywords
This publication has 30 references indexed in Scilit:
- Gap genes and gradients – The logic behind the gapsBioEssays, 1991
- Making stripes in the Drosophila embryoTrends in Genetics, 1990
- A cellular basis for pattern formation in the insect epidermisTrends in Genetics, 1989
- Molecular mechanisms governing species-specific transcription of ribosomal RNACell, 1989
- Evolutionary divergence of promoters and spacers in the rDNA family of four Drosophila speciesJournal of Molecular Biology, 1987
- An underlying repeat in some transcriptional control sequences corresponding to half a double helical turn of DNACell, 1986
- A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA-binding activityCell, 1984
- Molecular drive: a cohesive mode of species evolutionNature, 1982
- Dynamics of concerted evolution of ribosomal DNA and histone gene families in the melanogaster species subgroup of DrosophilaJournal of Molecular Biology, 1982
- Ribosomal RNA transcription in vitro is species specificNature, 1982