Peristalsis evoked by 5‐HT and renzapride: evidence for putative 5‐HT4 receptor activation
Open Access
- 1 March 1991
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 102 (3), 563-564
- https://doi.org/10.1111/j.1476-5381.1991.tb12211.x
Abstract
The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum. Both agents evoked the reflex at subthreshold intraluminal pressures (50% of threshold) and were blocked by ICS 205–930 (3 μm), but not ondansetron (5 μm). This novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-HT4 receptor.Keywords
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