5‐Fluoroorotate: a new liposome‐dependent cytotoxic agent
- 22 July 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 187 (1), 73-75
- https://doi.org/10.1016/0014-5793(85)81217-5
Abstract
The potency of 5‐fluoroorotate for inhibition of L929 or CV1‐P cell growth is increased by encapsulation in negatively charged liposomes. The optimal liposome composition is dipalmitoylphosphatidylglycerol: cholesterol, 67:33. Unextruded large unilamellar liposomes are the optimal size for delivery. This compound is the second transport‐negative drug which we have found to exhibit liposome‐dependent delivery.Keywords
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