The approach to treatment of regionally recurrent or inoperable cancers has had its impetus from the dynamic and forwardthinking studies of Oscar Creech and his associates.1-7 The most striking results have been obtained with melanomas of the extremities.6,8,9 Other areas have also been explored by the perfusion technique, and although the results are not as spectacular as extremity perfusion, significant palliation has been obtained. Areas of interest available to regional perfusion, include the brain, head and neck, breast, lung, liver, abdomen, and pelvis. Many excellent recent reports have reviewed the approaches and methods of treatment of these various areas.1,3-5,10-12 The results, in terms of palliation, in most of these areas have been gratifying, as reported. It is our purpose here to describe our approach to the regional perfusion of the pelvis. Applicable tumors, indications for perfusion and techniques of perfusion, choice of agent used, complications, and results