Vincent's stomatitis is becoming recognized as a distinct clinical entity. This disease may appear as the end result of many debilitating diseases. More often it appears in healthy individuals, but its main requirement to appear in epidemic form is poor mouth hygiene and crowded quarters. Confronted by an epidemic of Vincent's stomatitis in an institution in which end results could be observed, we decided to give nearly every logical treatment a fair trial and observe the results. It had been proved that Vincent's organisms are obligate anaerobes and cannot exist in the presence of oxygen; consequently we would resort to oxidizing agents for assistance when our cases did not do well. The pathogenicity of these organisms is still questioned, but destruction of these organisms eradicated the pathologic condition. Leeuwenhoek1in 1683 told the Royal Society about a new kind of creature that he found in the mouth of a