Blastogenic response of normal lymphocytes to cultured lymphoid cells and non-lymphoid neoplastic cells.

Abstract

Irradiated cultured lymphoid cells (normal and leukaemic) unequivocally stimulated the peripheral lymphocytes from twelve normal individuals. However, irradiated cultured non-lymphoid neoplastic cells (KB cells, melanoma cells and osteogenic sarcoma cells) exerted little or no stimulating effect on lymphocytes of the same donors. These findings indicate that something more than a simple HL-A incompatability is involved in this mixed cell interaction.