Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism
- 11 November 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 242 (4880), 941-944
- https://doi.org/10.1126/science.3263703
Abstract
Manganous superoxide dismutase (MnSOD) scavenges potentially toxic superoxide radicals produced in the mitochondria. Tumor necrosis factor-alpha (TNF-alpha) was found to induce the messenger RNA for MnSOD, but not the mRNAs for other antioxidant or mitochondrial enzymes tested. The increase in MnSOD mRNA occurred rapidly and was blocked by actinomycin D, but not by cycloheximide. Induction of MnSOD mRNA was also observed with TNF-beta, interleukin-1 alpha (IL-1 alpha), and IL-1 beta but not with other cytokines or agents tested. TNF-alpha induced MnSOD mRNA in all cell lines and normal cells examined in vitro and in various organs of mice in vivo. These effects of TNF-alpha and IL-1 on target cells may contribute to their reported protective activity against radiation as well as their ability to induce resistance to cell killing induced by the combination of TNF-alpha and cycloheximide.This publication has 59 references indexed in Scilit:
- The role of cachectin/TNF in endotoxic shock and cachexiaImmunology Today, 1988
- Tumour necrosis factor-α in murine autoimmune 'lupus' nephritisNature, 1988
- Purification and characterization of human fibroblast‐derived hybridoma growth factor identical to T‐cell‐derived B‐cell stimulatory factor‐2 (interleukin‐6)European Journal of Biochemistry, 1987
- Cytotoxicity of tumor necrosis factor for thyroid epithelial cells and its regulation by interferon‐γEuropean Journal of Immunology, 1987
- Tumor necrosis factor provokes superoxide anion generation from neutrophilsBiochemical and Biophysical Research Communications, 1986
- Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in VitroScience, 1985
- Tumor Necrosis Factor (TNF)Science, 1985
- Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cellsNature, 1985
- Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxinNature, 1984
- Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activityNature, 1984