Reactions to Live-Measles-Virus Vaccine in Children Previously Inoculated with Killed-Virus Vaccine

Abstract

ONE of the recommended technics of vaccination against measles is to give a course of killed-measles-virus vaccine followed, after an interval of months, by a booster of live attenuated measles virus either accompanied or unaccompanied by gamma globulin.¹ This technic is advocated as preventing the untoward reactions that may accompany the administration of the live virus even when gamma globulin is given coincidentally.In a certain number of these children, a local and, sometimes, general reaction may follow the final inoculation of the live-virus vaccine and may be severe enough to bring the child to the physician. This may occur . . .