THYROXINE AND TRIIODOTHYRONINE LEVELS IN HYPERTHYROID PATIENTS DURING TREATMENT WITH PROPRANOLOL
- 1 July 1977
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 7 (1), 41-44
- https://doi.org/10.1111/j.1365-2265.1977.tb02938.x
Abstract
Serum triiodothyronine (T3) and thyroxine (T4) levels were measured in twelve hyperthyroid patients before and after treatment with propranolol, 40 mg four times daily, for 2 weeks. There was a significant fall in serum T3 and a significant rise in serum T4 concentrations in the group as a whole and it was concluded that the clinical effectiveness of propranolol in hyperthyroidism may be mediated in part by its action on the peripheral metabolism of thyroid hormones. Propranolol treatment should be withdrawn gradually as removal of the suppressive action of the drug on thyroid hormone metabolism is potentially hazardous, particularly in patients with ischaemic heart disease.This publication has 13 references indexed in Scilit:
- REDUCED ACTIVE THYROID HORMONE LEVELS IN ACUTE ILLNESSThe Lancet, 1976
- Reciprocal Changes in Serum Concentrations of 3,3′,5′-Triiodothyronine (Reverse T3) and 3,3′5-Triiodothyronine (T3) in Systemic IllnessesJournal of Clinical Endocrinology & Metabolism, 1975
- A Radioimmunoassay for Measurement of 3,3′, 5′-Triiodothyronine (Reverse T3)JCI Insight, 1974
- BETA-BLOCKADE AND PARTIAL THYROIDECTOMY FOR THYROTOXICOSISThe Lancet, 1974
- EFFECT OF PROPRANOLOL ON SERUM-THYROXINEThe Lancet, 1970
- New Tactics for Hyperthyroidism: Sympathetic BlockadeAnnals of Internal Medicine, 1970
- PROPRANOLOL AND THE UTILIZATION OF RADIOIODINE BY THE HUMAN THYROID GLANDActa Endocrinologica, 1969
- CONTROLLED TRIAL OF PROPRANOLOL IN THYROTOXICOSISThe Lancet, 1969
- PROPRANOLOL AND IODINE-131 IN THE MANAGEMENT OF THYROTOXICOSISThe Lancet, 1968
- A Comparison of Three Beta‐Adrenergic Receptor‐Blocking Drugs in Thyrotoxic TachycardiaThe Journal of Clinical Pharmacology and The Journal of New Drugs, 1968