Antagonism of Ethanol Narcosis in Mice by Hyperbaric Pressures of 4–8 Atmospheres

Abstract
Hyperbaric treatment with 100% oxygen or oxygen-helium mixtures at 4–8 atmospheres absolute significantly reduced ethanol sleep-time and increased wake-up blood ethanol concentrations in C57 mice. The results indicate that the antagonsim does not result from direct effects of oxygen nor from enhanced ethanol elimination, but appears to involve a direct effect of hyper-baric treatment.