MORPHOLOGY AND DNA CONTENT OF ENDOMETRIAL CANCER NUCLEI UNDER PROGESTOGEN TREATMENT

Abstract

Twelve human endometrial cancers were observed before and during progestogen treatment. Eight were well differentiated and displayed an objective response. It was essentially characterized by a volumeric reduction of the nucleus and the disappearance of tetraploid nuclei. The DNA content remained diploid or near diploid. Reduction of nuclear non-DNA proteins under hormonal treatment is suggested.