Prolonging Effective Penicillin Action

Abstract

(1) Single injections of penicillin in saline administered intramuscularly with ice applications at the site of the injection produced and maintained bacteriostatic levels for six to twelve hours in nine out of ten patients, nine of whom were diagnosed as having gonorrhea and one urethritis with extracellular diplococci. (2) There was one failure, Subject No. 10, who received only 30,000 units. (3) Eight of the patients with gonorrhea and the one patient with urethritis were cured (bacteriologically and clinically) by this single intramuscular injection of penicillin.