Cerebral Gigantism
- 1 June 1977
- journal article
- editorial
- Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine
- Vol. 131 (6), 625-627
- https://doi.org/10.1001/archpedi.1977.02120190019001
Abstract
In 1964 cerebral gigantism emerged as a syndrome. The original five patients grew excessively during the first four years of life and had advanced height, weight, and bone age thereafter. They had distinctive facies, large dolichocephalic heads, hypertelorism, antimongoloid slant of the palpebral features, high arched palates, long arm span, and large hands and feet. Four of the five children were mentally retarded and clumsy; yet none showed gross neurological abnormalities. Pneumoencephalography revealed enlarged ventricles in three of the patients. After ruling out all the known causes of excessive growth, such as neurofibromatosis, Marfan's syndrome, adrenogenital syndrome, thyrotoxicosis, and excessive growth hormone secretion, to name a few, the authors concluded that the pattern of clinical findings failed to conform to any of the recognized causes of tall stature and that the remarkable similarity among the cases justified their grouping as a syndrome.1 Thirteen years have passed, and there areThis publication has 12 references indexed in Scilit:
- Prominent lateral palatine ridges: Developmental and clinical relevanceThe Journal of Pediatrics, 1976
- Sotos' Syndrome (Cerebral Gigantism) with Peripheral DysostosisArchives of Disease in Childhood, 1971
- Autonomic failure with persistent fever in cerebral gigantism.Journal of Neurology, Neurosurgery & Psychiatry, 1969
- Cerebral GigantismArchives of Pediatrics & Adolescent Medicine, 1969
- Cerebral gigantism: Endocrinological and clinical observations of six patients including a congenital giant, concordant monozygotic twins, and a child who achieved adult gigantic sizeThe Journal of Pediatrics, 1967
- Radiographic Findings in Hypothalamic Acceleration of Growth Associated With Cerebral Atrophy and Mental Retardation (Cerebral Gigantism)Radiology, 1967
- Dermatoglyphics in pediatric practiceThe Journal of Pediatrics, 1966
- Cerebral GigantismActa Paediatrica, 1965
- Cerebral Gigantism in ChildhoodNew England Journal of Medicine, 1964
- Hereditary Factors in the Sutural Pattern of the SkullActa Radiologica, 1951