CD2 is involved in regulating cyclic AMP levels in T cells
- 1 June 1988
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 18 (6), 961-964
- https://doi.org/10.1002/eji.1830180620
Abstract
The human T lymphocyte‐specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP comparable to that induced by reagents which activate adenylate cyclase. These results indicate that there is a relationship between the CD2 membrane molecule and the adenylate cyclase system.Keywords
This publication has 25 references indexed in Scilit:
- Activation of interleukin-2 receptor gene by Forskolin and cyclic AMP analoguesBiochemical and Biophysical Research Communications, 1987
- The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3Nature, 1987
- Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.The Journal of Experimental Medicine, 1987
- Involvement of the CD4 molecule in a post‐activation event on T cell proliferationEuropean Journal of Immunology, 1987
- Transmembrane signalling via the T11‐dependent pathway of human T cell activation. Evidence for the involvement of 1,2‐diacylglycerol and inositol phosphatesEuropean Journal of Immunology, 1987
- CD2 and CD3 antigens mobilize Ca2+ independentlyEuropean Journal of Immunology, 1985
- Involvement of T11 molecules in antigen receptormediated T lymphocyte functions: effect of anti-T11 monoclonal antibody on functional capabilities of alloreactive T cell clonesEuropean Journal of Immunology, 1985
- An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor proteinCell, 1984
- Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.Proceedings of the National Academy of Sciences, 1982
- Modulation of Inflammation and Immunity by Cyclic AMPScience, 1974