Correcting an immune-response deficiency by creating Eα gene transgenic mice
- 1 July 1985
- journal article
- Published by Springer Nature in Nature
- Vol. 316 (6023), 38-42
- https://doi.org/10.1038/316038a0
Abstract
We have introduced a cloned Ek alpha gene into embryos of mice incapable of expressing their endogenous E alpha genes. The transcription of Ek alpha was accurate and tissue-specific in the resulting transgenic lines and, in macrophages, Ek alpha transcription could be induced by gamma-interferon. The injected gene conferred on the genetically deficient host strain the ability to mount an immune response to a synthetic polymer.Keywords
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