Metabolism of C13-Carboxyl-labeled Malonate by the Intact Mouse

Abstract

When C13-carboxyl-labeled malonate was injd. subcut. into mice, 20-32% of the labeled C was recovered in the respiratory CO2 in 6 hours. At body temp. dog plasma showed little or no ability to decarboxylate malonate. These results are interpreted to indicate the probable occurrence in mammalian cells of enzymatic mechanisms for conversion of malonate to CO2.