Catalytic Antibodies with Lipase Activity and R or S Substrate Selectivity
- 28 April 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 244 (4903), 437-440
- https://doi.org/10.1126/science.2717936
Abstract
The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (10(3) to 10(5] above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.This publication has 37 references indexed in Scilit:
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