Synthesis of (+)-Methyl (R,E)-6-Benzyloxy-4-hydroxy-2-hexenoate and Its Mesylate Derivative
- 1 February 1995
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 25 (3), 331-342
- https://doi.org/10.1080/00397919508011364
Abstract
Methyl (E)-6-benzyloxy-4-hydroxy-2-hexenoate is prepared in both racemic and enantiopure form through reaction between (2-benzyloxy)ethyloxirane and the dianion of phenylselenoacetic acid followed by esterification with diazomethane, oxidation to the selenoxide and subsequent pyrolysis in 72% overall yield.Keywords
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