STREPTOMYCIN THERAPY IN INFECTION OF URINARY TRACT

Abstract

The development of resistance by bacteria to chemotherapeutic agents in the treatment of infectious diseases is becoming of increasing importance. With the wide usage of the sulfonamides and penicillin at present and probably of streptomycin in the near future, the problem of the development of fastness by organisms in the body during the period of treatment is a matter of great concern to the clinician. The manner in which organisms frequently become resistant to sulfonamide compounds is well recognized.¹ Development of fastness to penicillin has been observed² in some organisms during therapy but occurs much less frequently than fastness to sulfonamide compounds. Failure of organisms to readily develop a fastness to penicillin is probably one of the main reasons for the great effectiveness of this agent. With the newer antibiotic, streptomycin, however, the ease and speed with which organisms become resistant to it in vivo may prove to