Prenatal ethanol exposure in mice: Teratogenic effects
- 1 June 1979
- journal article
- research article
- Published by Wiley in Teratology
- Vol. 19 (3), 305-311
- https://doi.org/10.1002/tera.1420190305
Abstract
C57BL/6J mice were fed a liquid diet in which 17, 25, or 30% of the calories were derived from ethanol from the fifth through the tenth day of gestation. Control mice were fed lab chow or pair-fed identical diets, except that sucrose substituted isocalorically for ethanol. At term the fetuses were removed and. following fixation, examined by microdissection. The incidence of fetal resorptions and congenital malformations increased in a dose-related manner. Anomalies included skeletal, neurological, urogenital, and cardiovascular systems. These data indicate that in mice, an alcohol diet which is adequate in vitamins and protein results in increased fetal wastage and birth defects.This publication has 20 references indexed in Scilit:
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