Does gastric aminopyrine clearance reflect gastric mucosal blood flow or parietal cell function?
Open Access
- 1 December 1981
- Vol. 22 (12), 997-1002
- https://doi.org/10.1136/gut.22.12.997
Abstract
Gastric aminopyrine clearance was measured in human volunteers and dogs with untreated basal secretion, in human volunteers and dogs treated with secretory inhibitors, in dogs treated with histamine, and in patients with pernicious anaemia. When aminopyrine was given as a bolus to man or dog, aminopyrine clearance and the ratio aminopyrine concentration in gastric juice/aminopyrine concentration in plasma showed an initial peak two to three times over steady state levels. When aminopyrine was given with histamine, the peaks were even higher. No peaks occurred when an aminopyrine bolus was given to patients with pernicious anaemia or to healthy volunteers treated with secretory inhibitors. The height of the peaks paralleled the acid secretory rate. The peaks may best be explained by aminopyrine accumulation in the parietal cells and washing out of aminopyrine by volume flow. The steady state levels might reflect both parietal cell function and gastric mucosal blood flow.Keywords
This publication has 10 references indexed in Scilit:
- The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in manBritish Journal of Surgery, 1980
- Protein Precipitation by Acetone for the Analysis of Polyethylene Glycol in Intestinal Perfusion FluidGastroenterology, 1979
- Measurement of gastric mucosal blood flow in manGastroenterology, 1978
- CIMETIDINE AND GASTRIC BLOOD-FLOW1978
- Evaluation of [14C]Aminopyrine Clearance for Determination of Gastric Mucosal Blood FlowExperimental Biology and Medicine, 1976
- Comparison of gastric mucosal blood flow as determined by aminopyrine clearance and gamma-labeled microspheres.1975
- Comparison of Gastric Mucosal Blood Flow as Determined by Aminopyrine Clearance and γ-Labeled MicrospheresGastroenterology, 1975
- Oxygen consumption during thiocyanate inhibition of gastric acid secretion in dogsAmerican Journal of Physiology-Legacy Content, 1968
- Clearances of The Gastric MucosaGastroenterology, 1968
- THE GASTRIC SECRETION OF DRUGS - A PH PARTITION HYPOTHESIS1957