Triiodothyronine increases responsiveness of cultured rat bone cells to parathyroid hormone
- 1 February 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 111 (2), 213-216
- https://doi.org/10.1530/acta.0.1110213
Abstract
Osteoblast-like cells prepared from calvaria of newborn rats and grown in culture for 1 week show markedly increased ornithine decarboxylase (ODC) activity upon exposure to parathyroid hormone (PTH) for 4 h. Triiodothyronine (T3) increases ODC activity of the cultures in long-term experiments but does not stimulate cell replication. Moreover, PTH responsiveness is enhanced by T3. Thus, T3 acts directly on bone cells, and the clinical observation of bone sensitization to PTH by thyroid hormones is confirmed at the cellular level.This publication has 9 references indexed in Scilit:
- Insulin-like growth factors stimulate synthesis of nucleic acids and glycogen in cultured calvaria cellsCalcified Tissue International, 1983
- Thyroid function and bone turnoverActa Endocrinologica, 1983
- Ornithine decarboxylase (EC 4.1.1.17) assay based upon the retention of putrescine by a strong cation-exchange paperAnalytical Biochemistry, 1981
- Polyamine and differentiation: induction of ornithine decarboxylase by parathyroid hormone is a good marker of differentiated chondrocytes.Proceedings of the National Academy of Sciences, 1980
- Basal activities and hormone responsiveness of osteoclast-like and osteoblast-like bone cells are regulated by glucocorticoids.Journal of Biological Chemistry, 1979
- Glucocorticoid Receptors and Actions in Subpopulations of Cultured Rat Bone CellsJCI Insight, 1979
- Glucocorticoid Potentiation of the Adenosine 3′,5′- Monophosphate Response to Parathyroid Hormone in Cultured Rat Bone Cells*Endocrinology, 1978
- Direct stimulation of bone resorption by thyroid hormones.JCI Insight, 1976
- THE EFFECT OF THYROID DISEASE ON CALCIUM METABOLISM IN MAN 1JCI Insight, 1956